happychemist: (nerdhappy)
...and I'm not talking about the kind that gets you hyper. Ok, so it still may get me hyper. :p

Today, one of the assistant professors, Linda Hsieh-Wilson, gave a gorgeous lecture on her study on oligosaccharides and their role in regulating neurobiological processes. Not only is she a fantastic speaker, but she's done some incredible work. In honor of her, tonight's reading:

  • Murrey, Heather E.; Gama, Cristal I.; Kalovidouris, Stacey A.; Luo, Wen.-I.; Driggers, Edward M.; Porton, Barbara; Hsieh-Wilson, Linda C.. Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America (2006), 103(1), 21-26.
  • Gama, Cristal I.; Hsieh-Wilson, Linda C.. Chemical approaches to deciphering the glycosaminoglycan code. Current Opinion in Chemical Biology (2005), 9(6), 609-619.
  • Hsieh-Wilson, Linda C.. Tailor-made glycoproteins. Trends in Biotechnology (2004), 22(10), 489-491.

The laser is still down.
happychemist: (nerdhappy)
I've gotten inquiries as to what diazonamide (I typed it wrong the first time!) actually looked like and what it was. The thing is, the diazonamides have a really really cool story associated with them!!!

Click on pictures for larger views. Short story: the one she has on her back is 54 in the figure below.

Figure 1. Diazonamides A and B
from Ritter, Tobias; Carreira, Erick M. The diazonamides: the plot thickens. Angewandte Chemie, International Edition (2002), 41(14), 2489-2495.

The Long Story. *Brother Seamus voice* )


Feb. 16th, 2006 07:35 pm
happychemist: (Default)
Credit to [livejournal.com profile] the_marchioness for coining the term. :p

Yay for finishing chemistry early tonight! Am going home to settle in for tea, Mozart, and three papers:

  • Seyedsayamdost, Mohammad R.; Stubbe, JoAnne. Site-Specific Replacement of Y356 with 3,4-Dihydroxyphenylalanine in the b2 Subunit of E. coli Ribonucleotide Reductase. Journal of the American Chemical Society (2006), 128(8), 2522-2523.
  • Seyedsayamdost, Mohammad R.; Yee, Cyril S.; Reece, Steven Y.; Nocera, Daniel G.; Stubbe, JoAnne. pH Rate Profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli Ribonucleotide Reductase: Evidence that Y356 Is a Redox-Active Amino Acid along the Radical Propagation Pathway. Journal of the American Chemical Society (2006), 128(5), 1562-1568.
  • Seyedsayamdost, Mohammad R.; Reece, Steven Y.; Nocera, Daniel G.; Stubbe, JoAnne. Mono-, Di-, Tri-, and Tetra-Substituted Fluorotyrosines: New Probes for Enzymes That Use Tyrosyl Radicals in Catalysis. Journal of the American Chemical Society (2006), 128(5), 1569-1579.

Oh Fluoro-substituted tyrosines (and DOPA), you are so hot!


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